Showing posts with label fibromyalgia. Show all posts
Showing posts with label fibromyalgia. Show all posts

Wednesday, August 29, 2012

6 Natural Ways To Reduce Muscle Spasms And Pain

Dr. Mark Wiley | Aug 29, 2012

Why is muscle pain so prevalent today when hundreds of hands-on therapies, over-the-counter medications and do-it-yourself techniques for pain reduction are available almost any time of day? The reason is not that the pills, pain patches and therapies don’t work. Rather, the answer can most likely be found in your habits — known or unknown. The little things in your life, when combined day after day, can cause chronic muscle pain. Change those little things, and you can get big pain relief.

Muscles cramp, spasm and become painful for a number of reasons. Most of the more serious reasons, like serious medical illness and traumatic injury, are less common and certainly need proper diagnosis and treatment. For many people suffering with chronic muscle pain, inflammation, cramps and spasms, the reasons are less serious. However, they are nonetheless vital to address in order to stop the pain-and-inflammation cycle and reduce the frequency, severity and duration of attacks.

Essential things to do and keep in mind to help prevent muscle pain include:

Stay Hydrated With Plenty Of Pure Water
Water is one of the three essential things needed for life. (The others are oxygen and sunlight.) Water is so vital to life that life would not exist without it. While the human body is meant to be about 70 percent water, most people are chronically dehydrated. It is true that many people drink fluids throughout their day, yet they remain dehydrated. This happens when one consumes liquids that are diuretics.

Diuretics are substances that cause the body to excrete water. These include coffee, black tea, sodas and alcoholic beverages (particularly beer). When too many of these beverages are consumed, the body expels them quickly via urine and sweat. However, the body needs to retain enough purified fluids to maintain proper organ function, to remove toxins from the blood and to keep the skin moist. When water is low, toxins are not as easily processed or removed from the body and can begin recycling in the blood. This can cause pain, spasms and inflammation in the muscles.

Drinking eight to 10 glasses of pure or filtered water per day should bring you back to healthy levels within a few days. Some studies suggest people are habitually 2 quarts of water low. Others demonstrate that as long as your urine is clear, then your water levels are good. Start with counting how many glasses of water you consume, then check your urine. You will feel the difference and discover the levels you need.

Maintain Your Magnesium Levels
Magnesium is one of the essential minerals in the body that, when left unchecked, can lead to muscle pain, cramping, spasms and twitching. Magnesium helps all your organ systems function properly. Low levels of magnesium are a known cause of muscle pain. Most people need 300 mg to 400 mg of magnesium daily to help maintain proper functioning of the body. If supplementation is not your thing, then eating plenty of foods high in magnesium can do wonders. These include green leafy vegetables, whole grains and bran, soy beans, and pumpkin.

Here’s the scoop: Even if you get enough magnesium through diet or supplementation, your levels can still be decreased by internal causes. Irritable bowel syndrome (IBS), other gastrointestinal (GI) issues, diabetes, kidney disease or pancreatitis can be the cause of your decreased magnesium levels.

Maintain Your Potassium Levels
Like magnesium, potassium is essential to body function. When the body’s magnesium levels are low, they can negatively impact potassium levels. When potassium levels drop below 3.7 mEq/L, the body has what is known as hypokalemia, which causes one to become weak and feel fatigued and causes muscles to twitch and cramp. This is because potassium is necessary for nerve signals, muscle contractions and fluid balance.

Potassium is best ingested in natural food forms. It is found in fruits (most notably apricots, bananas, raisins and figs), wheat bran, wheat germ, dried fruits, mixed seeds, beans and vegetables. Most common cereals and breads are fortified with this mineral. If you think low potassium may be a cause of your muscle ailments, contact your local healthcare provider for the recommended blood screening.

Exercise And Stretch Every Day
Exercise is another simple thing that you can do every day to become healthier and prevent needless pain and inflammation. I know it is difficult to think about exercising when you are in pain. However, the main purpose of exercising for pain relief is to bolster blood flow. Even simple walking will help reduce your levels of muscle imbalances.

Walking for 30 minutes at an even pace, engaging in a simple stretching routine or participating in a yoga class will all help align the spine, keep the muscles supple and engender blood flow. When the blood is flowing well, a fresh supply of oxygen and nutrients move in the body, helping reduce pain and inflammation, repair the effects of stress and strain, and move toxins out of the body. Think of muscle spasms as stagnations of blood trapped in the tissue and causing pain.

Reduce Stress With Mind-Body Techniques
Do you rub your neck or low back constantly while at work or around certain people or events? This is stress making itself felt. Stress is a necessary part of life and of our survival. However, unhealthy stress can lead to excessive worry, anxiety, insomnia, improper breathing, muscle spasms and pain. While it is easy to suggest that you evaluate your life and remove all things and people that cause too much stress, this is not easily (or practically) done.

The good news is that there are quite a few simple mind-body techniques that can help reduce the effects and severity of stress. These include methods like biofeedback, mindful meditation, yoga, qigong, visualizations and hypnotherapy. Looking into some of these and putting them into daily practice will go a long way to reducing the negative effects of stress on the body.

Get A Good Night’s Sleep
Sleeping well is another essential element the body needs in order to repair and rebuild. Even with a diet rich in magnesium and potassium, plenty of water and exercise, and stress-reduction techniques, lack of ample deep sleep keeps the body from fully repairing itself. Sleeping at least seven hours in a position that will not cause you pain is necessary.

The secret to pain-free deep sleep is to set a standard sleep- and wake-time cycle. Not reading or drinking before bedtime also helps reduce insomnia and waking to urinate during the night. Sleeping on your back or on your side with a pillow between the knees will keep the spine in a supported position to decrease chances of pinched nerves or muscle spasms from poor sleep posture. The key is to get into the habit of regular sleep that allows you to wake up feeling refreshed and ready for the day — not stiff, tired and anxious.

In Summary
While some of the issues that can cause us to experience acute and chronic muscle pain and inflammation are beyond our control, many of them are completely within our power to change. If you experience daily muscle discomfort, the best thing you can do to help yourself is to get into a pattern of caring for yourself. In other words, be nice to yourself by not doing the things that can cause you more pain or discomfort and by doing the simple things that will help reduce and prevent a painful body. The six things mentioned in this article are keys to less pain. Incorporating them into your daily life will help in many ways.

 

Thursday, April 5, 2012

Dealing with Chronic Pain, Sleep and Relaxation

CVR

When You See it, You Can Achieve ItSimply put, visualization is the process of forming mental images; it is the primary component of the imagination.

Visualization is at the core of the human ability to create, innovate and dream.

Many of history's inventors and artists attribute their success to an exceptional ability to visualize. Thomas Edison, Nikola Tesla, Henry Ford, and the great composer, Chopin all reported using creative visualization to spark their imaginations. Additionally, Albert Einstein once said he came up with the theory of relativity by imagining what would happen if he could travel through space on the tip of a light beam.

Creative visualization can transport you out of a state of stress or fear, and into a new space of inner calm, peace and tranquility. Additionally, a natural byproduct of creative visualization occurs when the body goes loose and limp, creating the relaxation response - the perfect state for learning and focusing on goals.

Mind/Body Support

Visualization has long been the primary tool for mind/body support. From a scientific perspective, we know, that because visualization directly impacts the body's neurological system, it can have a direct influence on Visualize Thisus physically.

Try this for an example: Imagine I have just handed you a large, yellow, juice-filled lemon. You slice the lemon into quarters and bring one of the quarters to your mouth and bite into it . . . what happened? Did your mouth begin to pucker? Did it fill with saliva? This is a naturally occurring neurological response to an imagined thought.

Have you ever watched a horror film, and, in the midst of the excitement, found your palms sweating and your heart pounding? You knew it was "just a movie," right?

If your mind can cause this kind of impact on your body, is there any reason it can't relax your muscles, overpower nicotine, stimulate your metabolism, or even do away with chronic pain?

Anyone can relaxWhy Use Creative Visualization and Guided Relaxation Together?

We all have an inner critic, a part of our mind which, based on past experience, rejects unfamiliar information without proper evaluation. This is known as the critical factor. Studies show that relaxation techniques subdue this critical factor, making you receptive to new ideas. Even though it may seem counterintuitive to "let go in order to gain control," this is exactly what happens during the relaxation response.

Through NewReality's visualization techniques, you experience positive and appropriate ways to imagine your personal goals. This helps you remain optimistic and motivated toward changes that bring about your success.

CVR Provides the Missing Link to Wellness

Improved memoryRecent research shows excessive stress can suppress the immune system. Therefore, it's vital to incorporate a program of stress reduction and relaxation into your everyday routine. By reducing anxiety and stress, and increasing relaxation, you can boost your immune system and use your own unlimited resources to improve your life.

But don't think CVR is only a nice, relaxing daydream. People who regularly relax with CVR processes enjoy a number of side-benefits. These may include:

Increased blood flow to the brain, resulting in clearer thinking, better concentration, improved memory and enhanced creativity
  • A 21% increase in serotonin, which calms the mind and body and creates an overall sense of wellbeing
  • A 25% increase in endorphins, the hormones that flow through your body when you feel happy
  • Regular users sleep betterBetter sleep patterns. Twenty minutes of CVR can be equivalent to 2-3 hours of sleep, so you may find yourself sleeping less, feeling more rested, accomplishing more, and finding extra enjoyment in life
  • Soaring energy levels
  • More fulfilling relationships
  • Improved career satisfaction
  • A clearer sense of purpose
  • And last, but certainly not least, a seemingly effortless ability to manage stress

Saturday, November 26, 2011

Restless Leg Syndrome Linked To Fibromyalgia

October 19, 2010 A new study says adults with fibromyalgia have a much higher prevalence and risk of RLS than anyone else.

According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, it is estimated 5 million Americans age 18 or older area affected by Fibromyalgia. Fibromyalgia can cause significant pain and fatigue and the causes still remain unknown. RLS is a sleep-related movement disorder that involves an urge to move the legs that is usually accompanied or caused by uncomfortable and unpleasant sensations in the legs. Now researchers of Loyola University Medical Center are saying treating RLS may improve sleep and quality of life in people with fibromyalgia.
They studied 172 people with fibromyalgia and then compared them with 63 people with no signs of the disease. Pain was assessed by subjective report and by measurement with a dolorimeter, a spring-loaded gauge that is used to apply standardized rates of pressure to tender points on the arms and legs.

Results showed that the prevalence of restless legs syndrome was about 10 times higher in the fibromyalgia group than it the healthier group. After taking under consideration their age, gender and ethnicity, participants with fibromyalgia were 11 times more likely than controls to have RLS. In the fibromyalgia group these sleep problems were more severe among people who also had RLS.
"Sleep disruption is common in fibromyalgia, and often difficult to treat," contributing author Dr. Nathaniel F. Watson, associate professor of neurology at the University of Washington in Seattle, Wash. was quoted saying. "It is apparent from our study that a substantial portion of sleep disruption in fibromyalgia is due to restless legs syndrome."

SOURCE: Journal of Clinical Sleep Medicine, October 2010 as reported on Invanhoe.com

Restless Leg & Fibromyalgia

MyocalmPM works well for many to alleviate symptoms of restless leg syndrome & sleep.

November 25, 2010 The Journal of Clinical has just published a study this October revealing a substantial association between RLS (restless leg syndrome) and fibromylagia. This association is so powerful that persons with fibromylagia are eleven times more of a possibility to have RLS then those persons in the general populace.
 
Both of these conditions incline to keep those who endure the conditions to stay awake at night. RLS a neurological disorder identified by strange feeling that run through the legs linked with the uncontrollable desire to move the legs in hopes of providing relief. Persons who endure this disorder describe the feelings as burning, tugging and as if incests were crawling inside the legs. The feeling extend from minor discomfort to immense pain. In contrary fibromylagia is a complicated condition with vast range of symptoms. Until of late, a lot health practitioners did not recognize fibromylagia as a condition but merely as a person imaging things. As the same in both in conditions the cause is still unknown. Fibromylagia produces numerous tender areas in the muscles and joints included on places of the back and neck, knees and elbows and causes fatigue, general body aches, low tolerance for exercise and enduring facial muscle pain and aching. Fibromylagia cases appear in 85% of women.

The association between these two conditions was explained in the journal. A study conducted had observed 172 persons enduring fibromylagia. Among them 93% were women. The average age was fifty years old. Comparisons to a control group of persons who did not endure pain and fatigue with an average age of forty-one years old. Researchers had discovered 33% of the group with fibromylagia also had RLS compared to 3.1% of the control group.

Dr. Nathaniel F. Watson, Associate Professor of Neurology at the University of Washington in Seattle and one of the researchers commented in a news release that sleep disturbances is usual for persons with fibromylagia and most of the time is hard to treat. According to the study it is obvious that a major part of sleep disruptions in fibromylagia is caused by RLS.

Conventional medicine usually treats RLS with medications in hopes for improvement in sleep and the overall condition of those persons who also have fibromylagia. This treatment type goes way back to 1996 in which had discovered the same association of these two conditions. When the advocated treatment consisted of prescribed medications which had included colonazepan in hopes of bringing RLS under some form of control. The side effects of that particular drug had included dizziness, blurred vision and muscle pain. Not too much other other ones such as weight gain, depression and suicidal thoughts. It also brought up severe skin reactions that in some cases had proved fatal.

Now in current day we still have the medications which are used. These include a drug Mirapex, that contain its own ongoing list of side effects including sleeplessness, nausea, vomiting and compulsive behaviors. Of course there is also Valium and its side effects which include sleeplessness, vomiting and in severe reactions can include muscle loss, depression, rage, tremors and sleeplessness. The medication list keeps on going with almost nearly all similar side effects.

Many persons today use alternative treatments in order to treat both fibromylagia and RLS when they have the conditions at the same time. There are some alternative treatments that have been proven effective in the treatment of both of these conditions. A few of the most noted ones are listed.

Chiropractic
Chiropractic care has been known to be the top choice in alternative treatments to treat both of these debilitating conditions. It has been shown to greatly decrease the excruciating pain, incapacitating fatigue and joint stiffness all associated to fibromylagia.
In recent surveys nine out of ten patients suffering from RLS have found relief from through symptoms with chiropractic treatments. The treatments can provide the correcting of extremely instability in the feet, knees, ankles and hips. Adjustments made to the pelvic and lumbo-sacral instability.

Along with different manipulation techniques exercises such as leg stretching may be recommended along with nutritional advice and herbal supplements.

Acupuncture
Acupuncture is another popular choice of persons who endure either one or both of these conditions.
Acupuncture study on fibromylagia was conducted by the Mayo Clinic. Their findings had indicated that after acupuncture treatments major improvements was found in patients in the area of fatigue and anxiety. Even though according to the study it did decrease pain, an additional choice treatment such as pain medication was indicated.

Acupuncture on RLS symptoms has been noted to reduce stress and fatigue. It is still suggested to also use another alternative treatment in combination with acupuncture for greater decrease of symptoms.

Acupressure may also be used for those who just do not like needles and provide the same outcomes.

Supplements
Magnesium used for both conditions. By not having enough magnesium in the body conditions of can cause sleep disturbances such as in those of RLS. When used for fibromylagia it has been noted that it may aide in pain reduction.

Calcium has also been used for both of the conditions. Abnormal levels of neurotransmitters release muscle contractions. These levels have been seen in persons with fibromylagia who suffer from RLS at the same time. Calcium is usually taken as a supplement. Currently there are supplements which combine calcium and vitamin D.

Herbs
Melatonin has been used for both conditions. It is taken as a sleep aide and can cause drowsiness in daytime hours. It is recommended to avoid driving and exercise until you know how this herb effects your system.

Skullcap is also used as a sleep aide. Please note Chinese Skullcap is used as a sleep aide. American Skullcap is a mild relaxer for anxiety. These are two totally different herbs.
Valerian even though used for muscle pain and spasms it is also used as a sleep aide.
Kava Kava before bedtime can relax muscles in both cases.

Tia Chi
Due to this gentle form of movement which is slow it provides health benefits including muscle strength and flexibility. Studies have shown Tia Chi is a helpful for many conditions including arthritis, heart disease, fibromylagia and RLS.

Yoga
For persons with fibromyalagia it can reduce symptoms by at least 30% in areas include pain, fatigue, and stiffness. Which indirectly yields benefits for those with RLS the daily stretching and meditation that comes from yoga often decreases the symptoms in RLS.

Massage Therapy
Myofascial Release techniques is both fibromyalagia and RLS.
In fibromyalagia it decreases pain in the bodies fascia, which is brought on my myofascial pain. Fascia is a thin layer of tissues which covers all muscles and organs in the body. In persons with fibromyalagia the fascia becomes very short and tense producing pain. This therapy uses stretching techniques which decrease the pain.

In RLS this same techniques is used to help decrease the tingling sensation which is felt in the legs allowing for a more restful sleep.

Diet
There are four foods in which are in common to be eliminated from the diet for either condition or as in some cases both. Chocolate, coffee, alcohol and carbonated beverages. These things heighten fatigue and pain. They also have the ability to lower levels of blood glucose.

A healthy balanced diet is recommended in both conditions which include consuming four or five smaller meals instead of three large meals. It will maintain all muscles to function properly.
Processed foods in general are not a healthy idea. They contain massive amounts of saturated fats that cause interference with the circulatory system not to mention can cause pain and fatigue.
Consume plenty of fluids which include water, fresh juice and even herbal teas.

Source: AllVoice.com by Debbie Nicholson

Relieving Fibromyalgia

Music Therapy Aids in Relieving Fibromyalgia

May 27, 2011 Spanish researchers have discovered an innovative, non-pharmacological method to help individuals suffering from fibromyalgia — music therapy.

In a new study, University of Granada researchers showed that music therapy in association with guided imagery or other relaxation techniques significantly reduced pain, relieved depression and anxiety and improve sleep.

Experts believe use of music therapy and guided imagery allows people to have more control over their body, thereby enhancing personal well-being.

The research was conducted with patients suffering from fibromyalgia from the provinces of Granada, Almería and Córdoba, Spain. Study participants were evaluated at the beginning of the treatment, four weeks after the intervention, and eight weeks after the intervention, at the end of the study. The researchers utilized a relaxation technique based on guided imagery and music therapy to patients.

Patients were given a CD to listen at home. Then, researchers measured a number of variables associated with the main symptoms of fibromyalgia including pain intensity, quality of life, impact of the condition on patient’s daily life, sleep disorders, anxiety, depression, self-efficacy and well-being. Patients were also able to participate in their own treatment by learning how they could obtain symptomatic relief.

While the method helps individuals obtain relief, additional studies are needed to address other physiological variables associated with well-being, the researchers said.

Source: Pysch.com

Ribose to Promote Energy

Dr. Roizen Discusses Ribose to Promote Energy

February 11, 2009 Michael Roizen MD, author and Chief Wellness Officer at the Cleveland Clinic, was interviewed today. Much of his talk centered around ribose, a naturally occuring sugar compound that may help boost energy levels.
 
In their latest book, You: Being Beautiful -- The Owner's Manual to Inner and Outer Beauty, co-authors Mehmet Oz, MD and Michael Roizen, MD refer to ribose as one of the decade's "real nutritional heroes" that can "turbo-charge" those who need an energy boost.

Ribose is a naturally occurring 5-carbon sugar the body uses to stimulate the production of adenosine triphosphate (ATP) -- an essential energy compound. Although ribose is produced by the body, this energy molecule cannot be replenished fast enough during certain times of demanding exercise, stress, or as a result of many chronic diseases.

When added to foods and dietary supplements, D-Ribose enhances the body's natural process of energy synthesis. It reduces the loss of energy during stress, and accelerates energy and tissue recovery and the management of free radicals.

Source: WKYC.com/news/health

Monday, November 21, 2011

Optimized Energy for Serious Mitochondrial Needs

ATP Fuel™ - NEWOptimized Energy for Serious Mitochondrial Needs

ATP Fuel™ is designed to support the Krebs Cycle of cellular energy production. The Krebs Cycle takes place inside the mitochondria or “power plant” of the cell and it is the body’s primary energy producer.

ATP Fuel™ offers the top three energy nutrients and cofactors synergistically combined for maximum mitochondrial performance and energy production:

NT Factor Energy™
NADH
CoQ10
ATP Fuel™ starts with the base of our highly acclaimed NT Factor Energy™, and adds the two other well-researched energy producing nutrients, NADH and CoQ10 into one convenient and power-producing formula. Plus ATP Fuel™ is available in capsules.

NT Factor Energy™- to repair mitochondrial membranes NT Factor Energy™ was developed as a phospholipid delivery system to repair mitochondrial membranes that have been compromised due to acute and/or long-term health challenges.

Mitochondrial membranes contain their own DNA. If these membranes are damaged and not able to self-repair, they rely on healthy cells to donate their phospholipids. However, if there is a cascading impact of damaged cells splitting, the end result is a less than optimal energy level.

The product's efficacy is based on our proprietary method of extracting and stabilizing the phospholipids, and delivering them intact in the lower intestine for proper absorption. Phospholipids are very unstable and often oxidize in the manufacturing process or in the digestive tract before they can be presented for absorption in the lower intestine. After we stabilize the phospholipids, we wrap them in probiotics and prebiotics. Next, we add minerals and other nutrients to assist in the Krebs Energy Cycle and absorption. When the capsule reaches the lower intestine, the pre and probiotics are released first to promote a healthy flora. We follow this with the release of the NT Factor portion, whose matrix very closely matches that of the gastro intestinal mucosa. As these phospholipids are transported from cell to cell, they are absorbed into the outer and inner mitochondrial membranes --- allowing the mitochondria to provide its natural and healthy level of energy.

A healthy mitochondrial membrane:

allows more nutrients into the mitochondria to support the Krebs Cycle of energy production

is essential for the electron transport chain to efficiently produce healthy levels of ATP
promotes healthier (reduced) level of oxidative stress

NADH - to convert food into energy

NADH is the reduced (electron- energy rich) coenzyme form of vitamin B3 or B-Nicotinamide Adenine Dinucleotide. This "reducing" power (its ability to donate electrons) is what drives ATP production.

NADH is fundamental in the chemical process of converting the food we eat into cellular energy. Each unit of NADH creates three units of ATP (the body's energy fuel).

Studies conducted in Europe indicated that NADH promotes healthy energy levels and emotional balance.

NADH is notoriously unstable. As part of the Researched Nutritionals proprietary formula, we stabilize our NADH with chlorophyll, followed by microencapsulation process to resist gastric acids.

Coenzyme Q10 - for ATP energy production
Coenzyme Q10 (CoQ10) is a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 is involved in the making of ATP. ATP serves as the cell's major energy source and drives a number of biological processes including muscle contraction and the production of protein. CoQ10 also works as an antioxidant.

CoQ10 promotes healthy energy levels, enhances the immune system, and acts as an antioxidant. A growing body of research suggests that using coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements supports the body’s health in promoting a healthy heart, promoting healthy periodontal (gum) condition, and in supporting cognitive and nerve health.*

Mitochondria - what are they & why are they so important? Mitochondria are the primary energy producers in the body. The typical cell contains an average of 1,000 mitochondria. Given that there are 10 to the 13th power cells in a healthy adult, healthy and productive mitochondria are critical to maintain the body's energy and resilience.

Recent studies have shown the importance to maintaining healthy MTDNA, the DNA which resides inside the mitochondria. Unlike standard DNA which has histones and introns to protect it from free radical damage, the mitochondrial DNA does not have this protective mechanism so it is much more exposed and more susceptible to oxidative damage (ROS or reactive oxidative stress). And since mitochondrial cell division takes place approximately every five to six days and replicates the damage existing in the old cells, the damaged MTDNA spreads rapidly. This is what eventually depletes the patient's energy level and may lead to abnormal cellular formation.

Sunday, July 31, 2011

Energy Multi-Plex™ - Adrenal Support Formula

Adrenal Support Formula with 14 researched nutrients

Our product developers were assigned the task of developing the most advanced adrenal support product based on published research. After a thorough review of the literature, they formulated Energy Multi-Plex™ --- the total energy formula. A favorite among doctors and patients, Energy Multi-Plex™ is a reasonably priced answer to many people's dreams of more energy.

“I have improved energy after supplementing with NT Factor Energy and Energy Multi-Plex. Especially notable are the increased maximal sudden power, endurance, and ability to recover during exercise and also for the next day events - for example in distance bicycling on hilly roads and weight lifting and aerobic exercising at the Y.

These two Researched Nutritionals products were added to a thorough treatment program for a longer-term fatigue illness from tick borne infection complex illness in the later, more recent stages of therapy. I think the products address some of what we know about mitochondrial damage in the longer-term fatigue- like syndromes and look forward to discussing this further with others interested in increased energy. I have no conflicts of interest in my dialogues regarding Researched Nutritionals products.” --- H. Smith MD

Each bottle provides a one month supply of the following complexes and health benefits:

Energymax™ Complex:
Targeted blend of D-ribose, panax ginseng which

• promotes healthy energy levels by raising the level of the body’s energy fuel, ATP

• supports healthy cognitive performance

MuscularEnergy™ Complex:
Combination of malic acid and rhodiola rosea which

• plays a key role in energy producing Kreb’s Cycle

• has an adaptogenic affect to support physical activity

Mitrochondria Energizer™ Complex:
Powerful duo of acetyl-L-carnitine and alpha lipoic acid which

• acts as a catalyst for ATP production in mitochondria

• improves mitochondrial function while promoting healthy cognitive function

Metabolism Plus™ Complex:
Natural, non-stimulation blend of pyruvic acid and 7-Keto DHEA which

• naturally increases, without artificial stimulation, resting metabolism

• multiple studies
show increased fat utilization (fat loss) as an energy source

• promotes fat loss through thermogenesis

HeartStrong™ Complex:
High potency Co Q10 and L-Taurine which

• is used by the body to transform food into adenosine triphosphate (ATP), the energy on which the body runs

• promotes healthy heart and gum tissue

• modulates the immune system

• promotes healthy heart beat and cell wall stability

Key Nutrient Blend:
pantothenic acid, vitamin B-12, magnesium and potassium which

• are essential nutrients involved in producing, transporting and releasing energy from fat

• promotes healthy neuromuscular function and muscle contractions

Suggested Use

As a dietary supplement, take three capsules per day (at one time or throughout the day) or as directed by your healthcare professional.

Friday, May 20, 2011

RibosCardio™ with CardioPerform

RibosCardio™ with CardioPerform
Medical Food with Bioenergy Ribose, L-Carnitine, Acetyl L-Carnitine, Malic Acid and Magnesium GET ALL THE GREAT INGREDIENTS OF BIOENERGY CORVALENM PLUS MORE!

Special Dietary Usefulness as a Medical Food
Under a physician’s direction, RibosCardio™ may have special dietary usefulness for individuals suffering from energy-draining conditions, such as heart disease, Fibromyalgia, chronic fatigue syndrome, and Lyme disease. Published research has also shown D-Ribose effective in extending endurance exercise & increasing exercise tolerance, and muscle recovery from high intensity exercise.

RibosCardio™ has been designed to support serious energy needs of patients. The product has been formulated with CardioPerform™, a potent blend of L-carnitine (transports fuel into the heart to be burned as energy) and Acetyl L-carnitine (improves heart & brain health, protecting against oxidative damage), plus the patented form of D-Ribose, malic acid and magnesium gluconate to optimize energy production and synthesis.

Published research shows our patented form of D-ribose may be an effective adjunct in promoting cardiovascular, skeletal muscle, and neurological health. With heart patients, D-ribose has been found effective in restoring energy, improving ventilatory efficiency, oxygen uptake, stroke volume, diastolic function, physical performance, and quality of life. In neuromuscular disease, D-ribose helps to reduce pain, overcome fatigue, increase exercise tolerance, and help patients live more normal, active lives.

RibosCardio™'s magnesium gluconate and malic acid help your body use energy more efficiently. Your cells use magnesium in over 300 enzyme reactions, and it distributes energy evenly throughout the cell so it is available when and where it is needed. Malic Acid helps your mitochondria recycle the energy you have, maximizing cellular energy output.

D-Ribose Research Highlights
Cardiovascular Function: Scientific and clinical studies have repeatedly shown that our patented D-Ribose can restore energy and improve function in ischemic, hypoxic, and failing hearts. Oxygen deprivation causes hearts to use energy faster than it can be replaced through normal processes of tissue energy turnover. The result is a depletion of cellular energy reserves translating to a loss of heart function.

Mid-study results of an ongoing double blind, crossover trial with congestive heart failure patients were recently reported. Results showed conclusively that when patients were given ribose (15 grams per day for three weeks) they had improved diastolic heart function, increased physical function score and enhanced quality of life score. Echocardiographic studies of these patients showed that ribose administration enhanced relaxation of the left ventricle and improved the efficiency of filling from the left atrium. No such improvements were found during placebo administration (3).

RibosCardio™ increases cardiac energy to help fuel the heart. For patients, this can mean more energy and a higher quality of life.

Sports Nutrition:
In skeletal muscle, high-intensity exercise can lead to a loss of up to 26% of cellular adenosine triphosphate, or ATP. One consequence of this energy drain is an increase in free radicals in affected muscle. Free radicals attack cell and mitochondrial membranes and can destroy the genetic material that helps muscle tissues synthesize proteins.

RibosCardio™ helps in three ways:
First, if enough ribose is present in the cell or the circulating blood, energy compounds can be saved, or salvaged, before they wash out of the cell and are lost.

Second, ribose accelerates energy synthesis, so if energy compounds are lost, they can be quickly replaced.

Finally, by keeping the energy compounds in the cell, RibosCardio™ reduces free radical formation and preserves the energy the tissue needs to make proteins essential for maintaining muscle health and performance. This energy improvement has been shown to increased performance over time.
A study published in the journal, Current Therapeutic Research, showed that male recreational bodybuilders experienced a significant improvement in both muscular endurance (20% increase over the four weeks versus a 12% for the placebo group) and muscular endurance (3.2% increase over the four weeks versus a 1.7% for the placebo group) following 28 days of our patented D-Ribose supplementation(1).

Fibromyalgia & Chronic Fatigue Syndrome:
The muscle in patients with FMS and CFS is generally severely energy starved. This lack of energy leads to a number of physiological reactions within the muscle cell, ending in debilitating fatigue, muscle pain, soreness, and stiffness. By increasing the energy level in affected muscle, our patented D-Ribose helps patients overcome fatigue, and lessens the pain associated with their conditions.

Jar Size:
421 grams (15 oz) 28 day supply

Directions:
RibosCardio™ may be taken with other foods approved for your diet. Add one level scoop (two and 1/2 teaspoonfuls) to 4-8 ounces of your favorite juice, stir briskly and drink. As an alternative, sprinkle on cereal, fruit or applesauce.

Dosage:
Normal dosage is twice daily. Up to 4 doses per day may be taken as needed. If moderate to severe symptoms are present (as frequently seen in fibromyalgia and chronic fatigue syndrome) it is recommended that at least three doses per day be taken for the first two weeks before reducing dosage to twice per day. For best results, all doses should be taken no later than 3:00PM. Continued use is required to maintain the benefits of RibosCardio™.

Source:
Ribose is a fermentation process. The initial source is corn syrup. However, as the product is processed, all traces of corn are removed.

Soothe & Relaxx

Soft tissue, joint & muscle support with Relaxx™ Complex to calm the mind

Special Dietary Usefulness:
Under a physician’s direction, Soothe & Relaxx™ may have special dietary usefulness for individuals suffering from fibromyalgia and other chronic illnesses with soft tissue, joint and muscle pain.

Soothe & Relaxx™ was developed to meet the combination of needs that many chronically ill patients experience: pain and anxiety. The product addresses pain as a result of soft tissue or joint injury and the concomitant anxiety often associated with long-term health issues. The Relaxx™ Complex is designed to take the edge off versus being a sedating micro-formula. This is a favorite of patients who feel the benefit fairly quickly.

Each bottle provides a one month supply of the following complexes and health benefits:

Pro Joint Soothers™:
Proprietary blend of glucosamine sulfate, MSM, chrondroitin sulfate, hyaluronic acid which supports connective tissue, lubricates joints, promotes joint resilience, elasticity and overall strength.

ExInflame™ Complex:
Proprietary blend of White Willow Bark, Boswellin, Curcumin Extract, Holy Basil which promotes a healthy inflammation response.

Muscle & Leg Calmer™:
Proprietary blend of magnesium hydroxide and malic acid which calms muscle contractions and relaxes the body's muscles.

Relaxx™ Complex:
Proprietary blend of 5HTP, Valerian, Lemon Balm, Passion Flower, German Chamomile which relaxes & calms the mind, and promotes healthy sleep patterns.

Suggested Use:
As a dietary supplement, take two capsules three times per day or as directed by your health care professional.

Energy for Serious Mitochondrial Needs

ATP Fuel™ - NEW
Optimized Energy for Serious Mitochondrial Needs

ATP Fuel™ is designed to support the Krebs Cycle of cellular energy production. The Krebs Cycle takes place inside the mitochondria or “power plant” of the cell and it is the body’s primary energy producer.

ATP Fuel™ offers the top three energy nutrients and cofactors synergistically combined for maximum mitochondrial performance and energy production:

NT Factor Energy
NADH
CoQ10
ATP Fuel™ starts with the base of our highly acclaimed NT Factor Energy™, and adds the two other well-researched energy producing nutrients, NADH and CoQ10 into one convenient and power-producing formula. Plus ATP Fuel™ is available in capsules.

NT Factor Energy™- to repair mitochondrial membranes NT Factor Energy™ was developed as a phospholipid delivery system to repair mitochondrial membranes that have been compromised due to acute and/or long-term health challenges.

Mitochondrial membranes contain their own DNA. If these membranes are damaged and not able to self-repair, they rely on healthy cells to donate their phospholipids. However, if there is a cascading impact of damaged cells splitting, the end result is a less than optimal energy level.

The product's efficacy is based on our proprietary method of extracting and stabilizing the phospholipids, and delivering them intact in the lower intestine for proper absorption. Phospholipids are very unstable and often oxidize in the manufacturing process or in the digestive tract before they can be presented for absorption in the lower intestine. After we stabilize the phospholipids, we wrap them in probiotics and prebiotics. Next, we add minerals and other nutrients to assist in the Krebs Energy Cycle and absorption. When the capsule reaches the lower intestine, the pre and probiotics are released first to promote a healthy flora. We follow this with the release of the NT Factor portion, whose matrix very closely matches that of the gastro intestinal mucosa. As these phospholipids are transported from cell to cell, they are absorbed into the outer and inner mitochondrial membranes --- allowing the mitochondria to provide its natural and healthy level of energy.

A healthy mitochondrial membrane:

allows more nutrients into the mitochondria to support the Krebs Cycle of energy production

is essential for the electron transport chain to efficiently produce healthy levels of ATP

promotes healthier (reduced) level of oxidative stress

NADH - to convert food into energy

NADH is the reduced (electron- energy rich) coenzyme form of vitamin B3 or B-Nicotinamide Adenine Dinucleotide. This "reducing" power (its ability to donate electrons) is what drives ATP production.

NADH is fundamental in the chemical process of converting the food we eat into cellular energy. Each unit of NADH creates three units of ATP (the body's energy fuel).

Studies conducted in Europe indicated that NADH promotes healthy energy levels and emotional balance.

NADH is notoriously unstable. As part of our proprietary formula, we stabilize our NADH with chlorophyll, followed by microencapsulation process to resist gastric acids.

Coenzyme Q10 - for ATP energy production
Coenzyme Q10 (CoQ10) is a compound found naturally in the energy-producing center of the cell known as the mitochondria. CoQ10 is involved in the making of ATP. ATP serves as the cell's major energy source and drives a number of biological processes including muscle contraction and the production of protein. CoQ10 also works as an antioxidant.

CoQ10 promotes healthy energy levels, enhances the immune system, and acts as an antioxidant. A growing body of research suggests that using coenzyme Q10 supplements alone or in combination with other drug therapies and nutritional supplements supports the body’s health in promoting a healthy heart, promoting healthy periodontal (gum) condition, and in supporting cognitive and nerve health.*

We source our CoQ10 from the highest quality Japanese raw material, ensuring optimal bioavailability.

Mitochondria - what are they & why are they so important? Mitochondria are the primary energy producers in the body. The typical cell contains an average of 1,000 mitochondria. Given that there are 10 to the 13th power cells in a healthy adult, healthy and productive mitochondria are critical to maintain the body's energy and resilience.

Recent studies have shown the importance to maintaining healthy MTDNA, the DNA which resides inside the mitochondria. Unlike standard DNA which has histones and introns to protect it from free radical damage, the mitochondrial DNA does not have this protective mechanism so it is much more exposed and more susceptible to oxidative damage (ROS or reactive oxidative stress). And since mitochondrial cell division takes place approximately every five to six days and replicates the damage existing in the old cells, the damaged MTDNA spreads rapidly. This is what eventually depletes the patient's energy level and may lead to abnormal cellular formation.

Suggested Use:
Take five capsules 30 minutes before breakfast and five capsules before lunch or dinner (ten capsules per day) for the first two months, and five capsules before breakfast in month 3 and beyond. It is important to keep with the protocol for the first two months so that enough cell membranes are repaired --- which will allow the patient to feel the difference. This equates to 2 bottles per month for each of the first two months, and 1 bottle per month thereafter.

Tuesday, February 15, 2011

GINGER CURE FOR MUSCLE PAIN

GINGER CURE FOR MUSCLE PAIN
You’ve experienced muscle soreness after a workout, right? You give it your all at the gym, on the tennis court, in the pool -- and then, ouch. Well, here’s an easy, safe, natural and inexpensive cure that will mean you don’t have to treat yourself so gingerly -- take ginger!
Long used in traditional Indian and Chinese medicine as a remedy for ailments such as nausea, indigestion, flatulence, flu, diarrhea, motion sickness and osteoarthritis, ginger (Zingiber officinale) now has been scientifically proven to be helpful in relieving muscle pain and soreness. A new study shows that taking daily doses of ginger can ease the aches and pains that follow strenuous exercise.

THE GINGER STUDY
Researchers at the University of Georgia studied whether daily doses of ginger can inhibit exercise-related muscle pain. One group of 34 participants consumed capsules filled with two grams of raw (untreated) ginger (this is equivalent to the 500-mg capsules of raw ginger sold in health-food stores). A second group of 40 people took two grams of heat-treated ginger (earlier studies had shown that heating ginger may increase its pain-relieving properties). A third group took a placebo. All participants consumed their capsules for 11 consecutive days -- seven days before... the day of... and three days after a high-intensity weight-lifting session (designed to induce muscle pain and inflammation) performed on the eighth day.
Measuring several different variables, including effort and pain intensity (reported by participants)... range of motion... strength... and levels of prostaglandins (inflammation-mediators involved in pain), researchers found that...
• Participants taking daily raw ginger supplements reported 25% less exercise-induced pain than the placebo group.
• Participants taking daily heat-treated ginger had 23% less pain than the placebo group.

WHY GINGER HELPS
Patrick O’Connor, PhD, led the research study. He told me that ginger works much like nonsteroidal anti-inflammatory drugs (NSAIDs, such as aspirin and ibuprofen) do, by inhibiting prostaglandin production. Unlike NSAIDs, ginger also serves to desensitize a type of pain receptor found in the peripheral nerves known as TRPV1 and it also reduces the body’s production of inflammatory chemicals called cytokines, said Dr. O’Connor. These results were published in the September 2010 issue of The Journal of Pain.
Muscle aches and pains are common among athletes -- particularly serious ones, older ones and weekend warriors. If you fall into any of those categories, you may want to consider taking ginger to minimize your post-workout agony. Although this study didn’t test the efficacy of ginger against NSAIDs, Dr. O’Connor told me that the study participants experienced greater pain relief than did those in similar tests of ibuprofen and naproxen, but without the NSAID-related risks of stomach irritation and ulcers.

TRY IT AT HOME
If you’d like to give this a try, Dr. O’Connor suggests purchasing ginger capsules that contain a standardized extract with a gingerol content of 5%. Take one two-gram daily dose for several days before and after planned workouts.

If you love the taste of ginger: Kitchen equivalents are as follows -- a two-gram dose of raw ginger in capsule form is roughly equivalent to one teaspoon of powdered ginger... 2 milliliters (about one-half teaspoon) of ginger extract ... or (my favorite) one tablespoon of finely chopped fresh ginger.
Source(s):

Patrick O'Connor, PhD, professor and codirector, exercise psychology laboratory, The University of Georgia, Athens, Georgia.

JESorganics.com

Saturday, May 29, 2010

Skeletal Muscle Abnormalities in Patients with Fibromyalgia

Skeletal Muscle Abnormalities in Patients with Fibromyalgia
Download PDF

Widespread muscle pain and tender points are the most common complaints of fibromyalgia patients, and the underlying mechanisms responsible for these symptoms have been studied intensively during the past decade. It has been suggested that fatigue and pain may lead to decreased levels of physical activity in many patients. The resulting deconditioned state may itself contribute to muscle abnormalities. Associated symptoms such as disturbed sleep, anxiety, depression, or irritable bowel also may have a negative impact on muscle function and level of daily activities. The important interactions between the central nervous and musculoskeletal systems may involve another element, the neuroendocrine stress-response system. This review will consider both the current state of knowledge and also future studies which might be designed to answer more effectively the outstanding questions regarding the underlying pathogenesis of fibromyalgia.
Renowned Cardiothoracic Surgeon Calls Ribose Results "Astounding" (Buy Ribose at the best lowest price with free shipping)

Pioneering Beating Heart CABG Doc Presenting ATS Paper on Using Ribose to Rebuild the Energy Supply of the Heart Prior to Bypass Surgery

MINNEAPOLIS, MN. , April 25, 2006 – Even though he has performed the highest percentage of Beating Heart Coronary Artery Bypass Grafting (also called Off Pump CABG) procedures of any doctor in the U.S. since 1990, Dr. David Perkowski was still looking for improvement. Treating his patients with Bioenergy D-Ribose before surgery proved to be just what the doctor ordered, as a paper being presented to the American Thoracic Society International Conference in San Diego May 19 – 24 will show.

"We did a controlled study with two groups of our off-pump patients with one group using ribose and one not using ribose," explains Perkowski, Chief of Cardiothoracic Surgery at Saddleback Memorial in Laguna Hills, California. "In the ribose group we saw an improvement in cardiac index that was 30-percent higher than the non-treated group, which is quite astounding. An improvement in the cardiac index means the heart is able to pump more blood to the body with each heartbeat. With the ribose supplementation the heart can recruit energy more effectively helping it to simply pump better. So now we are using the ribose in most of our patients. This data is very important in real-world cardiac surgery, and it’s exciting!"

Perkowski has collected data from over 140 patients and he is presenting this landmark study on ribose to the American Thoracic Society.

Health care providers, insurance companies, and cardiac patients themselves are also excited about the prospect of avoiding the use of the heart-lung machine for a bypass procedure. Dr. Perkowski’s results show this procedure can now be utilized in more patients when ribose is used in their treatment regimen.

While the heart-lung machine is acknowledged as one of cardiac surgery’s most important inventions, there are risks associated with stopping the heart and temporarily replacing its functions with a machine. Those risks include bleeding, major stroke and neurological problems.

Additionally, complete recovery for a traditional bypass surgery ranges from four to six weeks, while recovery for beating heart bypass procedures have been reported to be as short as three to four weeks. In many cases, the patient is out of the hospital within just a few days following surgery.

Ribose supplementation has also allowed Dr. Perkowski and his team to get critical cases to the operating table sooner.

"Typically as a cardiac surgeon we have to look at many parameters to ensure the safety of the operation. Without ribose, it would generally take seven to 10 days following a heart attack before we could do a beating heart bypass operation on a patient, even though their heart needed it sooner. With the ribose supplementation, now in many cases we can move that surgery up."

"Our patients are frequently elderly and have had coronary disease for a long time," continues Perkowski. "Sometimes their hearts can contract quite well, but they can’t fully relax. And what the ribose use allows us to do is help the heart relax so it can fill with blood more effectively for the next heartbeat. With the administration of ribose, the entire ventricle works better, and recovers in a shorter period of time. Ribose allows the operation to proceed in a much easier fashion."

All this after just a few doses of a simple, five-carbon sugar that is found in every cell of the human body? If it is so simple, yet so effective, why doesn’t the world know about it?

"Understanding what ribose does in the heart takes a good understanding of biochemistry and what is happening with the body at the cellular level," states Perkowski. "In my specific case, to do beating heart surgery we really had to investigate and know what was going on within the cell when it was normal and when it was damaged. We found the most important step in all of these enzymatic systems is the production of adenosine triphosphate, or ATP. It’s the energy currency of the cell and provides the power all cells need to function. So whatever can be done to aid or improve that process is going to be important for that cell, and ribose has been proven to significantly accelerate energy synthesis and recovery. It’s hard to believe it can be so effective, so quickly, but we’ve got the data to prove it."

There is one other number Dr. Perkowski hasn’t yet discussed, and it’s a significant one.

"Our predicted mortality rate with the ribose patients was between four-and-a-half to five percent. Our actual mortality rate with the ribose patients is zero. We think that is extremely important, particularly given the fact the patients we see belong to the oldest and highest risk group."

So what does Dr. Perkowski see for the future of ribose supplementation?

"Ribose today is a little bit like beating heart surgery was 10 or 15 years ago. Nobody thought back then we could do it, and now we can successfully operate on 98-percent of all first-time coronary bypass patients without having to use the heart-lung machine. I believe we will have a similar success story with ribose, although I hope it doesn’t take that long for it to be put to wider use."

Bioenergy Inc., is a privately-held, Minneapolis-based life sciences company whose core technology lies in the development and commercialization of products based on the physiological benefits of D-ribose in health and wellness. Bioenergy's clear mission is to develop products that increase quality of life by improving the function of hearts, muscles, and other body tissues. Valen Labs, Inc., its subsidiary, markets ribose-based products to the general and clinical nutrition markets. Valen Labs’ products include Bioenergy RIBOSE, a functional ingredient in the active lifestyle market; CORvalenTM, a clinical nutrition product giving metabolic support to heart patients; and CORvalenMTM, a nutritional supplement that helps relieve myalgia, muscle soreness, cramping and fatigue.

Medical Food with Bioenergy Ribose, L-Carnitine, Acetyl L-Carnitine, Malic Acid and Magnesium

BUY Medical Food with Bioenergy Ribose, L-Carnitine, Acetyl L-Carnitine, Malic Acid and Magnesium GET ALL THE GREAT INGREDIENTS OF BIOENERGY CORVALENM PLUS MORE!

Special Dietary Usefulness as a Medical Food
Under a physician’s direction, RibosCardio™ may have special dietary usefulness for individuals suffering from energy-draining conditions, such as heart disease, Fibromyalgia, chronic fatigue syndrome, and Lyme disease. Published research has also shown D-Ribose effective in extending endurance exercise & increasing exercise tolerance, and muscle recovery from high intensity exercise.

RibosCardio™ has been designed to support serious energy needs of patients. The product has been formulated with CardioPerform™, a potent blend of L-carnitine (transports fuel into the heart to be burned as energy) and Acetyl L-carnitine (improves heart & brain health, protecting against oxidative damage), plus the patented form of D-Ribose, malic acid and magnesium gluconate to optimize energy production and synthesis.

Published research shows our patented form of D-ribose may be an effective adjunct in promoting cardiovascular, skeletal muscle, and neurological health. With heart patients, D-ribose has been found effective in restoring energy, improving ventilatory efficiency, oxygen uptake, stroke volume, diastolic function, physical performance, and quality of life. In neuromuscular disease, D-ribose helps to reduce pain, overcome fatigue, increase exercise tolerance, and help patients live more normal, active lives.

RibosCardio™'s magnesium gluconate and malic acid help your body use energy more efficiently. Your cells use magnesium in over 300 enzyme reactions, and it distributes energy evenly throughout the cell so it is available when and where it is needed. Malic Acid helps your mitochondria recycle the energy you have, maximizing cellular energy output.

D-Ribose Research Highlights
Cardiovascular Function: Scientific and clinical studies have repeatedly shown that our patented D-Ribose can restore energy and improve function in ischemic, hypoxic, and failing hearts. Oxygen deprivation causes hearts to use energy faster than it can be replaced through normal processes of tissue energy turnover. The result is a depletion of cellular energy reserves translating to a loss of heart function.

Mid-study results of an ongoing double blind, crossover trial with congestive heart failure patients were recently reported. Results showed conclusively that when patients were given ribose (15 grams per day for three weeks) they had improved diastolic heart function, increased physical function score and enhanced quality of life score. Echocardiographic studies of these patients showed that ribose administration enhanced relaxation of the left ventricle and improved the efficiency of filling from the left atrium. No such improvements were found during placebo administration (3).

RibosCardio™ increases cardiac energy to help fuel the heart. For patients, this can mean more energy and a higher quality of life.

Sports Nutrition:
In skeletal muscle, high-intensity exercise can lead to a loss of up to 26% of cellular adenosine triphosphate, or ATP. One consequence of this energy drain is an increase in free radicals in affected muscle. Free radicals attack cell and mitochondrial membranes and can destroy the genetic material that helps muscle tissues synthesize proteins.

RibosCardio™ helps in three ways:
First, if enough ribose is present in the cell or the circulating blood, energy compounds can be saved, or salvaged, before they wash out of the cell and are lost.
Second, ribose accelerates energy synthesis, so if energy compounds are lost, they can be quickly replaced.

Finally, by keeping the energy compounds in the cell, RibosCardio™ reduces free radical formation and preserves the energy the tissue needs to make proteins essential for maintaining muscle health and performance. This energy improvement has been shown to increased performance over time.

A study published in the journal, Current Therapeutic Research, showed that male recreational bodybuilders experienced a significant improvement in both muscular endurance (20% increase over the four weeks versus a 12% for the placebo group) and muscular endurance (3.2% increase over the four weeks versus a 1.7% for the placebo group) following 28 days of our patented D-Ribose supplementation(1).

Fibromyalgia & Chronic Fatigue Syndrome:
The muscle in patients with FMS and CFS is generally severely energy starved. This lack of energy leads to a number of physiological reactions within the muscle cell, ending in debilitating fatigue, muscle pain, soreness, and stiffness. By increasing the energy level in affected muscle, our patented D-Ribose helps patients overcome fatigue, and lessens the pain associated with their conditions.

Jar Size:
421 grams (15 oz) 28 day supply

Directions:
RibosCardio™ may be taken with other foods approved for your diet. Add one level scoop (two and 1/2 teaspoonfuls) to 4-8 ounces of your favorite juice, stir briskly and drink. As an alternative, sprinkle on cereal, fruit or applesauce.

Dosage:
Normal dosage is twice daily. Up to 4 doses per day may be taken as needed. If moderate to severe symptoms are present (as frequently seen in fibromyalgia and chronic fatigue syndrome) it is recommended that at least three doses per day be taken for the first two weeks before reducing dosage to twice per day. For best results, all doses should be taken no later than 3:00PM. Continued use is required to maintain the benefits of RibosCardio™.

Source:
Ribose is a fermentation process. The initial source is corn syrup. However, as the product is processed, all traces of corn are removed.

Cautions: Insulin-dependent diabetics, pregnant women or patients with elevated uric acid levels should consult their physician before use.

Research Papers
1) Van Gammeren D, D Falk, J Antonio. The Effects of Four Weeks of Ribose Supplementation on Body Composition and Exercise Performance, Current Therapeutics Research 2002;63(8):486-495.

2) Jacob E. Teitelbaum, MD, CA Johnson, JA St.Cyr MD,PhD. Effective Treatment Of Chronic Fatigue Syndrome And Fibromyalgia With D-Ribose J Alt Comp Med, 2006;12(6):857-862.

3) White Paper: D-Ribose in Congestive Heart Failure and Ischemic Disease Bioenergy Life Sciences.

Sunday, April 20, 2008

Research: Benefit of Ribose in a Patient With Fibromyalgia

Research: Benefit of Ribose in a Patient With Fibromyalgia

01-31-2005 Journal: PharmacotherapyBenjamin Gebhart, Pharm.D.; James A. Jorgenson, M.S., FASHP
Abstract and Introduction
Abstract

Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.

Introduction
Fibromyalgia is a syndrome that is manifested by generalized muscle pain and additional systemic symptoms of fatigue, tenderness and stiffness in multiple joints, sleep disturbance, and alterations in bowel activity.The specific etiology is unknown; however, changes in muscle histology, energy metabolism, oxygen utilization, and the neuroendocrine stress-response system have been postulated to play a role in the development and persistence of this disorder.

[1] Low levels of muscle adenine nucleotides, reflected in depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge, have been reported.[2-4] The unknown cause and varying presenting symptoms make fibromyalgia a therapeutic challenge for practitioners.[5-7]

Routine daily exercise programs, dietary modifications, alternative therapies such as biofeedback and hypnotherapy, and nutraceuticals such as S-adenosyl-L-methionine (SAMe) have also been explored.[9]
Unfortunately, less than 50% of patients achieve any meaningful relief of their symptoms with use of those therapies.[5]We describe the case of a patient with fibromyalgia who had symptomatic relief when ribose was added to her existing treatment regimen.

There have been anecdotal reports on the benefits of ribose in patients with fibromyalgia in whom conventional therapies have failed; however, to our knowledge, this is the first published case of use of ribose for this syndrome.

Case ReportA 37-year-old woman had daily episodes of intense musculoskeletal pain and stiffness, mental "cloudiness," bouts of diarrhea, and sleep disturbance. As she was a surgeon, these symptoms compromised the skills necessary to perform her daily duties in the operating room. She was diagnosed with fibromyalgia by exclusion of other diseases and syndromes and in accordance with the American College of Rheumatology criteria.[10]

The patient was treated with ibuprofen 800 mg twice/day, valdecoxib 10 mg once/day, diphenhydramine 50 mg-acetaminophen 1000 mg at bedtime, and physical therapy once/day. She stated that this therapeutic regimen had limited benefit and that the adverse effects from these drugs further impaired her ability to perform her operative duties.

Approximately 7 months later, in addition to her regular drug therapy, the patient began taking CORvalen (Bioenergy, Inc., Ham Lake, MN), a ribose-based product. She took 5 g of CORvalen mixed in water twice/day. She experienced no adverse effects, and after 14 days she reported a decrease in her symptoms. Specifically, she noted an improvement in sleep, mental alertness, a marked decrease in joint pain, and normal stools.

This trend continued, and after an additional month of CORvalen therapy she reported near-normal functioning with a major reduction in her symptoms.After another month of taking CORvalen and feeling "normal," the patient elected to discontinue the drug. Within 7 days, she regressed to her initial fibromyalgia state, as reflected in joint pain, sleep disturbance, morning stiffness, trigger-point flares, and diarrhea. She resumed taking CORvalen, at the same dosage as before, and a major reduction in her symptoms again occurred within 14 days. She noted continual benefit for the next month while taking CORvalen. She stopped taking the drug for a second time after this additional 30-day period, and once again she experienced a reemergence of symptoms.

When CORvalen was restarted for a third time, the patient's symptoms again subsided.At the time of this writing, the patient was continuing to take CORvalen and was satisfied that her symptoms had abated.DiscussionRibose is a simple carbohydrate that plays a role in high-energy phosphate and nucleic acid synthesis. After ischemia or hypoxia, myocytes have decreased levels of ATP and total adenine nucleotides. Several days are required for their recovery once normoxia has been reestablished.[11-13] In patients with chronic hypoxic conditions, the cellular energy charge may never be fully regained.[14]These cells have the capacity to regenerate ATP; however, the pentose phosphate pathway of glucose metabolism utilized in the formation of the ribose that is needed to drive the regenerative process is slow in both heart and skeletal muscle cells due to poor expression of specific rate-limiting enzymes.

Supplemental ribose has been shown to enhance the synthesis of adenine nucleotides, rebuilding depressed energy pools in both the heart and skeletal muscle after an ischemic or hypoxic insult.[11, 12] Ribose bypasses the rate-limiting enzymatic steps of the pentose phosphate pathway and accelerates the formation of ATP and subsequent tissue recovery.[15]

Supplemental ribose is initially converted to ribose-5-phosphate, subsequently forming 5-phosphoribosyl-1-pyrophosphate, a molecule key to the synthesis of ATP through the de novo purine nucleotide pathway. The safety of ribose has been investigated in standard laboratory and animal toxicology models and in human studies both subjectively and objectively.

Investigators have concluded that ribose is well tolerated at dosages of up to 60 g/day, with no significant adverse effects.[16]Ribose has been shown to improve the energy recovery time in skeletal muscle and to relieve fatigue, soreness, and stiffness after intense exercise.[12, 13, 17] It also has been reported to have a beneficial effect after high-intensity exercise in sports medicine.One study concluded that ribose accelerated the replenishment of ATP after intense muscle contractions,[18] and bodybuilders and sprinters have reported subjective and objective benefits during exercise after the administration of ribose.[18-20] However, other reports have shown inconsistent results for ribose in relation to improving short-term anaerobic exercise performance, muscle strength, endurance, or body composition during cycling or resistance training.[20, 21]

Ribose has also been investigated for its potential medical efficacy in both animal studies and human clinical trials. To date, the most promising data have been reported in connection with the application of ribose in cardiovascular disease. Both short-term and long-term animal studies found that the use of ribose after myocardial ischemia resulted in enhanced recovery of ATP along with improved diastolic functional parameters.[22, 23]

Clinical benefits have also been observed. Patients with coronary artery disease or heart failure have decreased myocardial ATP levels. Daily supplemental ribose has been shown to improve cardiac function, increase exercise tolerance, and enhance quality of life in this population.[24]Patients with fibromyalgia may experience an alteration in physiologic muscle metabolism. It has been found that they reach the anaerobic threshold in their muscles earlier, thereby using less of the available energy-rich phosphate metabolites at maximal work capacity.[25]

In another study, patients with fibromyalgia were reported to have a potential abnormality in high-energy phosphate metabolism, as evidenced by significantly lower levels of ATP and ADP in affected muscles as compared with patients without the disease.[2]

Theoretically, the effect of ribose on increasing the muscle energy pool could reduce the metabolic strain in affected muscles and allow patients to assume a more active lifestyle. Considering the known musculoskeletal symptomatology in this syndrome and the reported benefits of ribose in skeletal muscle metabolism and physiology, supplemental ribose appears to have aided our patient in improving her quality of life.

Conclusion
Fibromyalgia presents a continuing therapeutic challenge. Ribose is a naturally occurring carbohydrate with documented medical benefits in patients with cardiovascular disease. To our knowledge, this is the first report to suggest its potential benefit in a patient with fibromyalgia, who had had suboptimal results with conventional therapies. We are designing a trial using objective outcome measures to further evaluate the effectiveness of this product in patients with fibromyalgiaPharmacotherapy 24(11):1646-1648, 2004. © 2004

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Missing Nutrients

Many people, desperate for relief from constant suffering from fibromyalgia and chronic pain, have opted for surgery, physical therapy and/or pain medications, including anti-depressants, and still they say "I hurt all over."

Using prescription medications, such as antidepressants, tranquilizers and pain medications, only treats the symptoms. Prescription medications only use the current supply of neurotransmitters and nutrients and do not create any new neurotransmitters (the chemical language of the brain).

Pain, stress, anxiety and depression burn the amino acids and minerals the body must have for proper functioning. One must constantly replenish the brain with needed nutrients.

When nutrient deficiencies are reversed, then the problem is addressed and healing is enhanced. The proper nutrients can have a positive effect on pain and the anxiety and depression that come with it.

To focus on assisting those who suffer from FM and chronic pain, it is necessary to understand what is happening in the body and the brain. An increased level of muscle tissue breakdown has been suggested as one of the main reasons for aching, pain and fatigue. The onset may be gradual or sudden. Symptoms may appear after an illness or a traumatic or stressful episode in one's life.

FM can occur within the muscles or where muscles join their tendons, rather than in the joints. Tension and stress, poor posture, rapid repetitive motions or incorrectly using the muscles to push, lift or pull can aggravate FM.

Anxiety and depression will almost always follow.

A major factor in the successful treatment of FM, as well as chronic pain, is specific nutrients that exert a strong regenerative effect on the body's systems, including the nervous system.

Missing Nutrients

Recent research has shown that FM patients may be deficient in certain compounds required for the synthesis of ATP (Adenosine Triphosphate).

One of the most crucial elements for ATP synthesis is magnesium. Research suggests FM patients have below-normal levels of magnesium. Low levels of magnesium can contribute to PMS, headaches, muscle cramping, muscle spasms, heart palpitations and even heart attacks. Many common foods Americans eat deplete magnesium reserves. According to reports, at least 85 percent of magnesium is removed by eating bleached and refined flour in breads, pasta and other prepared wheat products.

Soft drinks have a high phosphorus content, which also reduces magnesium levels in the body. Even high-calcium supplementation, without adequate magnesium, will deplete the body's level of magnesium.

Malic Acid
Aluminum toxicity may play a role in symptoms experienced by magnesium-deficient FM patients. As a preventative measure, adequate amounts of magnesium can help block the toxic effects of aluminum. However, the most potent; aluminum detoxifier is malic acid. Malic acid is especially effective at decreasing aluminum toxicity in the brain. Alzheimer's Disease patients have been found to have unusually high levels of aluminum in their brains. It was once assumed that these people had ingested large amounts of aluminum during their lifetimes. However, while that may be true, it is now thought that how much aluminum is consumed is not nearly as important as how well our bodies can detoxify and eliminate the substance.

Treatment with malic acid has been shown to greatly increase the fecal and urinary excretion of aluminum and reduce the concentration of aluminum found in various organs and tissues.

Clinical tests are proving malic acid to be a great asset in the treatment of FM and chronic pain. In one clinical study, reported in "The Journal of Nutritional Medicine," 15 patients (aged 32-60) taking a dosage of 200-2400 mg. of maIic acid with 300-600 mg of magnesium for four to eight weeks, reported significant pain relief within 48 hours. These positive effects continued to increase over the test period.

The mineral manganese and B complex vitamins have also been shown to be deficient in both CFS (Chronic Fatigue Syndrome) and FM sufferers. Combinations of GABA, glutamine and glycine, (inhibitory neurotransmitters) have been helpful in lowering stress levels by controlling limbic firing in the brain.