Showing posts with label pain. Show all posts
Showing posts with label pain. Show all posts

Wednesday, August 29, 2012

6 Natural Ways To Reduce Muscle Spasms And Pain

Dr. Mark Wiley | Aug 29, 2012

Why is muscle pain so prevalent today when hundreds of hands-on therapies, over-the-counter medications and do-it-yourself techniques for pain reduction are available almost any time of day? The reason is not that the pills, pain patches and therapies don’t work. Rather, the answer can most likely be found in your habits — known or unknown. The little things in your life, when combined day after day, can cause chronic muscle pain. Change those little things, and you can get big pain relief.

Muscles cramp, spasm and become painful for a number of reasons. Most of the more serious reasons, like serious medical illness and traumatic injury, are less common and certainly need proper diagnosis and treatment. For many people suffering with chronic muscle pain, inflammation, cramps and spasms, the reasons are less serious. However, they are nonetheless vital to address in order to stop the pain-and-inflammation cycle and reduce the frequency, severity and duration of attacks.

Essential things to do and keep in mind to help prevent muscle pain include:

Stay Hydrated With Plenty Of Pure Water
Water is one of the three essential things needed for life. (The others are oxygen and sunlight.) Water is so vital to life that life would not exist without it. While the human body is meant to be about 70 percent water, most people are chronically dehydrated. It is true that many people drink fluids throughout their day, yet they remain dehydrated. This happens when one consumes liquids that are diuretics.

Diuretics are substances that cause the body to excrete water. These include coffee, black tea, sodas and alcoholic beverages (particularly beer). When too many of these beverages are consumed, the body expels them quickly via urine and sweat. However, the body needs to retain enough purified fluids to maintain proper organ function, to remove toxins from the blood and to keep the skin moist. When water is low, toxins are not as easily processed or removed from the body and can begin recycling in the blood. This can cause pain, spasms and inflammation in the muscles.

Drinking eight to 10 glasses of pure or filtered water per day should bring you back to healthy levels within a few days. Some studies suggest people are habitually 2 quarts of water low. Others demonstrate that as long as your urine is clear, then your water levels are good. Start with counting how many glasses of water you consume, then check your urine. You will feel the difference and discover the levels you need.

Maintain Your Magnesium Levels
Magnesium is one of the essential minerals in the body that, when left unchecked, can lead to muscle pain, cramping, spasms and twitching. Magnesium helps all your organ systems function properly. Low levels of magnesium are a known cause of muscle pain. Most people need 300 mg to 400 mg of magnesium daily to help maintain proper functioning of the body. If supplementation is not your thing, then eating plenty of foods high in magnesium can do wonders. These include green leafy vegetables, whole grains and bran, soy beans, and pumpkin.

Here’s the scoop: Even if you get enough magnesium through diet or supplementation, your levels can still be decreased by internal causes. Irritable bowel syndrome (IBS), other gastrointestinal (GI) issues, diabetes, kidney disease or pancreatitis can be the cause of your decreased magnesium levels.

Maintain Your Potassium Levels
Like magnesium, potassium is essential to body function. When the body’s magnesium levels are low, they can negatively impact potassium levels. When potassium levels drop below 3.7 mEq/L, the body has what is known as hypokalemia, which causes one to become weak and feel fatigued and causes muscles to twitch and cramp. This is because potassium is necessary for nerve signals, muscle contractions and fluid balance.

Potassium is best ingested in natural food forms. It is found in fruits (most notably apricots, bananas, raisins and figs), wheat bran, wheat germ, dried fruits, mixed seeds, beans and vegetables. Most common cereals and breads are fortified with this mineral. If you think low potassium may be a cause of your muscle ailments, contact your local healthcare provider for the recommended blood screening.

Exercise And Stretch Every Day
Exercise is another simple thing that you can do every day to become healthier and prevent needless pain and inflammation. I know it is difficult to think about exercising when you are in pain. However, the main purpose of exercising for pain relief is to bolster blood flow. Even simple walking will help reduce your levels of muscle imbalances.

Walking for 30 minutes at an even pace, engaging in a simple stretching routine or participating in a yoga class will all help align the spine, keep the muscles supple and engender blood flow. When the blood is flowing well, a fresh supply of oxygen and nutrients move in the body, helping reduce pain and inflammation, repair the effects of stress and strain, and move toxins out of the body. Think of muscle spasms as stagnations of blood trapped in the tissue and causing pain.

Reduce Stress With Mind-Body Techniques
Do you rub your neck or low back constantly while at work or around certain people or events? This is stress making itself felt. Stress is a necessary part of life and of our survival. However, unhealthy stress can lead to excessive worry, anxiety, insomnia, improper breathing, muscle spasms and pain. While it is easy to suggest that you evaluate your life and remove all things and people that cause too much stress, this is not easily (or practically) done.

The good news is that there are quite a few simple mind-body techniques that can help reduce the effects and severity of stress. These include methods like biofeedback, mindful meditation, yoga, qigong, visualizations and hypnotherapy. Looking into some of these and putting them into daily practice will go a long way to reducing the negative effects of stress on the body.

Get A Good Night’s Sleep
Sleeping well is another essential element the body needs in order to repair and rebuild. Even with a diet rich in magnesium and potassium, plenty of water and exercise, and stress-reduction techniques, lack of ample deep sleep keeps the body from fully repairing itself. Sleeping at least seven hours in a position that will not cause you pain is necessary.

The secret to pain-free deep sleep is to set a standard sleep- and wake-time cycle. Not reading or drinking before bedtime also helps reduce insomnia and waking to urinate during the night. Sleeping on your back or on your side with a pillow between the knees will keep the spine in a supported position to decrease chances of pinched nerves or muscle spasms from poor sleep posture. The key is to get into the habit of regular sleep that allows you to wake up feeling refreshed and ready for the day — not stiff, tired and anxious.

In Summary
While some of the issues that can cause us to experience acute and chronic muscle pain and inflammation are beyond our control, many of them are completely within our power to change. If you experience daily muscle discomfort, the best thing you can do to help yourself is to get into a pattern of caring for yourself. In other words, be nice to yourself by not doing the things that can cause you more pain or discomfort and by doing the simple things that will help reduce and prevent a painful body. The six things mentioned in this article are keys to less pain. Incorporating them into your daily life will help in many ways.

 

Saturday, November 26, 2011

Relieving Fibromyalgia

Music Therapy Aids in Relieving Fibromyalgia

May 27, 2011 Spanish researchers have discovered an innovative, non-pharmacological method to help individuals suffering from fibromyalgia — music therapy.

In a new study, University of Granada researchers showed that music therapy in association with guided imagery or other relaxation techniques significantly reduced pain, relieved depression and anxiety and improve sleep.

Experts believe use of music therapy and guided imagery allows people to have more control over their body, thereby enhancing personal well-being.

The research was conducted with patients suffering from fibromyalgia from the provinces of Granada, Almería and Córdoba, Spain. Study participants were evaluated at the beginning of the treatment, four weeks after the intervention, and eight weeks after the intervention, at the end of the study. The researchers utilized a relaxation technique based on guided imagery and music therapy to patients.

Patients were given a CD to listen at home. Then, researchers measured a number of variables associated with the main symptoms of fibromyalgia including pain intensity, quality of life, impact of the condition on patient’s daily life, sleep disorders, anxiety, depression, self-efficacy and well-being. Patients were also able to participate in their own treatment by learning how they could obtain symptomatic relief.

While the method helps individuals obtain relief, additional studies are needed to address other physiological variables associated with well-being, the researchers said.

Source: Pysch.com

Friday, May 20, 2011

RibosCardio™ with CardioPerform

RibosCardio™ with CardioPerform
Medical Food with Bioenergy Ribose, L-Carnitine, Acetyl L-Carnitine, Malic Acid and Magnesium GET ALL THE GREAT INGREDIENTS OF BIOENERGY CORVALENM PLUS MORE!

Special Dietary Usefulness as a Medical Food
Under a physician’s direction, RibosCardio™ may have special dietary usefulness for individuals suffering from energy-draining conditions, such as heart disease, Fibromyalgia, chronic fatigue syndrome, and Lyme disease. Published research has also shown D-Ribose effective in extending endurance exercise & increasing exercise tolerance, and muscle recovery from high intensity exercise.

RibosCardio™ has been designed to support serious energy needs of patients. The product has been formulated with CardioPerform™, a potent blend of L-carnitine (transports fuel into the heart to be burned as energy) and Acetyl L-carnitine (improves heart & brain health, protecting against oxidative damage), plus the patented form of D-Ribose, malic acid and magnesium gluconate to optimize energy production and synthesis.

Published research shows our patented form of D-ribose may be an effective adjunct in promoting cardiovascular, skeletal muscle, and neurological health. With heart patients, D-ribose has been found effective in restoring energy, improving ventilatory efficiency, oxygen uptake, stroke volume, diastolic function, physical performance, and quality of life. In neuromuscular disease, D-ribose helps to reduce pain, overcome fatigue, increase exercise tolerance, and help patients live more normal, active lives.

RibosCardio™'s magnesium gluconate and malic acid help your body use energy more efficiently. Your cells use magnesium in over 300 enzyme reactions, and it distributes energy evenly throughout the cell so it is available when and where it is needed. Malic Acid helps your mitochondria recycle the energy you have, maximizing cellular energy output.

D-Ribose Research Highlights
Cardiovascular Function: Scientific and clinical studies have repeatedly shown that our patented D-Ribose can restore energy and improve function in ischemic, hypoxic, and failing hearts. Oxygen deprivation causes hearts to use energy faster than it can be replaced through normal processes of tissue energy turnover. The result is a depletion of cellular energy reserves translating to a loss of heart function.

Mid-study results of an ongoing double blind, crossover trial with congestive heart failure patients were recently reported. Results showed conclusively that when patients were given ribose (15 grams per day for three weeks) they had improved diastolic heart function, increased physical function score and enhanced quality of life score. Echocardiographic studies of these patients showed that ribose administration enhanced relaxation of the left ventricle and improved the efficiency of filling from the left atrium. No such improvements were found during placebo administration (3).

RibosCardio™ increases cardiac energy to help fuel the heart. For patients, this can mean more energy and a higher quality of life.

Sports Nutrition:
In skeletal muscle, high-intensity exercise can lead to a loss of up to 26% of cellular adenosine triphosphate, or ATP. One consequence of this energy drain is an increase in free radicals in affected muscle. Free radicals attack cell and mitochondrial membranes and can destroy the genetic material that helps muscle tissues synthesize proteins.

RibosCardio™ helps in three ways:
First, if enough ribose is present in the cell or the circulating blood, energy compounds can be saved, or salvaged, before they wash out of the cell and are lost.

Second, ribose accelerates energy synthesis, so if energy compounds are lost, they can be quickly replaced.

Finally, by keeping the energy compounds in the cell, RibosCardio™ reduces free radical formation and preserves the energy the tissue needs to make proteins essential for maintaining muscle health and performance. This energy improvement has been shown to increased performance over time.
A study published in the journal, Current Therapeutic Research, showed that male recreational bodybuilders experienced a significant improvement in both muscular endurance (20% increase over the four weeks versus a 12% for the placebo group) and muscular endurance (3.2% increase over the four weeks versus a 1.7% for the placebo group) following 28 days of our patented D-Ribose supplementation(1).

Fibromyalgia & Chronic Fatigue Syndrome:
The muscle in patients with FMS and CFS is generally severely energy starved. This lack of energy leads to a number of physiological reactions within the muscle cell, ending in debilitating fatigue, muscle pain, soreness, and stiffness. By increasing the energy level in affected muscle, our patented D-Ribose helps patients overcome fatigue, and lessens the pain associated with their conditions.

Jar Size:
421 grams (15 oz) 28 day supply

Directions:
RibosCardio™ may be taken with other foods approved for your diet. Add one level scoop (two and 1/2 teaspoonfuls) to 4-8 ounces of your favorite juice, stir briskly and drink. As an alternative, sprinkle on cereal, fruit or applesauce.

Dosage:
Normal dosage is twice daily. Up to 4 doses per day may be taken as needed. If moderate to severe symptoms are present (as frequently seen in fibromyalgia and chronic fatigue syndrome) it is recommended that at least three doses per day be taken for the first two weeks before reducing dosage to twice per day. For best results, all doses should be taken no later than 3:00PM. Continued use is required to maintain the benefits of RibosCardio™.

Source:
Ribose is a fermentation process. The initial source is corn syrup. However, as the product is processed, all traces of corn are removed.

Soothe & Relaxx

Soft tissue, joint & muscle support with Relaxx™ Complex to calm the mind

Special Dietary Usefulness:
Under a physician’s direction, Soothe & Relaxx™ may have special dietary usefulness for individuals suffering from fibromyalgia and other chronic illnesses with soft tissue, joint and muscle pain.

Soothe & Relaxx™ was developed to meet the combination of needs that many chronically ill patients experience: pain and anxiety. The product addresses pain as a result of soft tissue or joint injury and the concomitant anxiety often associated with long-term health issues. The Relaxx™ Complex is designed to take the edge off versus being a sedating micro-formula. This is a favorite of patients who feel the benefit fairly quickly.

Each bottle provides a one month supply of the following complexes and health benefits:

Pro Joint Soothers™:
Proprietary blend of glucosamine sulfate, MSM, chrondroitin sulfate, hyaluronic acid which supports connective tissue, lubricates joints, promotes joint resilience, elasticity and overall strength.

ExInflame™ Complex:
Proprietary blend of White Willow Bark, Boswellin, Curcumin Extract, Holy Basil which promotes a healthy inflammation response.

Muscle & Leg Calmer™:
Proprietary blend of magnesium hydroxide and malic acid which calms muscle contractions and relaxes the body's muscles.

Relaxx™ Complex:
Proprietary blend of 5HTP, Valerian, Lemon Balm, Passion Flower, German Chamomile which relaxes & calms the mind, and promotes healthy sleep patterns.

Suggested Use:
As a dietary supplement, take two capsules three times per day or as directed by your health care professional.

Sunday, April 20, 2008

Research: Benefit of Ribose in a Patient With Fibromyalgia

Research: Benefit of Ribose in a Patient With Fibromyalgia

01-31-2005 Journal: PharmacotherapyBenjamin Gebhart, Pharm.D.; James A. Jorgenson, M.S., FASHP
Abstract and Introduction
Abstract

Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.

Introduction
Fibromyalgia is a syndrome that is manifested by generalized muscle pain and additional systemic symptoms of fatigue, tenderness and stiffness in multiple joints, sleep disturbance, and alterations in bowel activity.The specific etiology is unknown; however, changes in muscle histology, energy metabolism, oxygen utilization, and the neuroendocrine stress-response system have been postulated to play a role in the development and persistence of this disorder.

[1] Low levels of muscle adenine nucleotides, reflected in depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge, have been reported.[2-4] The unknown cause and varying presenting symptoms make fibromyalgia a therapeutic challenge for practitioners.[5-7]

Routine daily exercise programs, dietary modifications, alternative therapies such as biofeedback and hypnotherapy, and nutraceuticals such as S-adenosyl-L-methionine (SAMe) have also been explored.[9]
Unfortunately, less than 50% of patients achieve any meaningful relief of their symptoms with use of those therapies.[5]We describe the case of a patient with fibromyalgia who had symptomatic relief when ribose was added to her existing treatment regimen.

There have been anecdotal reports on the benefits of ribose in patients with fibromyalgia in whom conventional therapies have failed; however, to our knowledge, this is the first published case of use of ribose for this syndrome.

Case ReportA 37-year-old woman had daily episodes of intense musculoskeletal pain and stiffness, mental "cloudiness," bouts of diarrhea, and sleep disturbance. As she was a surgeon, these symptoms compromised the skills necessary to perform her daily duties in the operating room. She was diagnosed with fibromyalgia by exclusion of other diseases and syndromes and in accordance with the American College of Rheumatology criteria.[10]

The patient was treated with ibuprofen 800 mg twice/day, valdecoxib 10 mg once/day, diphenhydramine 50 mg-acetaminophen 1000 mg at bedtime, and physical therapy once/day. She stated that this therapeutic regimen had limited benefit and that the adverse effects from these drugs further impaired her ability to perform her operative duties.

Approximately 7 months later, in addition to her regular drug therapy, the patient began taking CORvalen (Bioenergy, Inc., Ham Lake, MN), a ribose-based product. She took 5 g of CORvalen mixed in water twice/day. She experienced no adverse effects, and after 14 days she reported a decrease in her symptoms. Specifically, she noted an improvement in sleep, mental alertness, a marked decrease in joint pain, and normal stools.

This trend continued, and after an additional month of CORvalen therapy she reported near-normal functioning with a major reduction in her symptoms.After another month of taking CORvalen and feeling "normal," the patient elected to discontinue the drug. Within 7 days, she regressed to her initial fibromyalgia state, as reflected in joint pain, sleep disturbance, morning stiffness, trigger-point flares, and diarrhea. She resumed taking CORvalen, at the same dosage as before, and a major reduction in her symptoms again occurred within 14 days. She noted continual benefit for the next month while taking CORvalen. She stopped taking the drug for a second time after this additional 30-day period, and once again she experienced a reemergence of symptoms.

When CORvalen was restarted for a third time, the patient's symptoms again subsided.At the time of this writing, the patient was continuing to take CORvalen and was satisfied that her symptoms had abated.DiscussionRibose is a simple carbohydrate that plays a role in high-energy phosphate and nucleic acid synthesis. After ischemia or hypoxia, myocytes have decreased levels of ATP and total adenine nucleotides. Several days are required for their recovery once normoxia has been reestablished.[11-13] In patients with chronic hypoxic conditions, the cellular energy charge may never be fully regained.[14]These cells have the capacity to regenerate ATP; however, the pentose phosphate pathway of glucose metabolism utilized in the formation of the ribose that is needed to drive the regenerative process is slow in both heart and skeletal muscle cells due to poor expression of specific rate-limiting enzymes.

Supplemental ribose has been shown to enhance the synthesis of adenine nucleotides, rebuilding depressed energy pools in both the heart and skeletal muscle after an ischemic or hypoxic insult.[11, 12] Ribose bypasses the rate-limiting enzymatic steps of the pentose phosphate pathway and accelerates the formation of ATP and subsequent tissue recovery.[15]

Supplemental ribose is initially converted to ribose-5-phosphate, subsequently forming 5-phosphoribosyl-1-pyrophosphate, a molecule key to the synthesis of ATP through the de novo purine nucleotide pathway. The safety of ribose has been investigated in standard laboratory and animal toxicology models and in human studies both subjectively and objectively.

Investigators have concluded that ribose is well tolerated at dosages of up to 60 g/day, with no significant adverse effects.[16]Ribose has been shown to improve the energy recovery time in skeletal muscle and to relieve fatigue, soreness, and stiffness after intense exercise.[12, 13, 17] It also has been reported to have a beneficial effect after high-intensity exercise in sports medicine.One study concluded that ribose accelerated the replenishment of ATP after intense muscle contractions,[18] and bodybuilders and sprinters have reported subjective and objective benefits during exercise after the administration of ribose.[18-20] However, other reports have shown inconsistent results for ribose in relation to improving short-term anaerobic exercise performance, muscle strength, endurance, or body composition during cycling or resistance training.[20, 21]

Ribose has also been investigated for its potential medical efficacy in both animal studies and human clinical trials. To date, the most promising data have been reported in connection with the application of ribose in cardiovascular disease. Both short-term and long-term animal studies found that the use of ribose after myocardial ischemia resulted in enhanced recovery of ATP along with improved diastolic functional parameters.[22, 23]

Clinical benefits have also been observed. Patients with coronary artery disease or heart failure have decreased myocardial ATP levels. Daily supplemental ribose has been shown to improve cardiac function, increase exercise tolerance, and enhance quality of life in this population.[24]Patients with fibromyalgia may experience an alteration in physiologic muscle metabolism. It has been found that they reach the anaerobic threshold in their muscles earlier, thereby using less of the available energy-rich phosphate metabolites at maximal work capacity.[25]

In another study, patients with fibromyalgia were reported to have a potential abnormality in high-energy phosphate metabolism, as evidenced by significantly lower levels of ATP and ADP in affected muscles as compared with patients without the disease.[2]

Theoretically, the effect of ribose on increasing the muscle energy pool could reduce the metabolic strain in affected muscles and allow patients to assume a more active lifestyle. Considering the known musculoskeletal symptomatology in this syndrome and the reported benefits of ribose in skeletal muscle metabolism and physiology, supplemental ribose appears to have aided our patient in improving her quality of life.

Conclusion
Fibromyalgia presents a continuing therapeutic challenge. Ribose is a naturally occurring carbohydrate with documented medical benefits in patients with cardiovascular disease. To our knowledge, this is the first report to suggest its potential benefit in a patient with fibromyalgia, who had had suboptimal results with conventional therapies. We are designing a trial using objective outcome measures to further evaluate the effectiveness of this product in patients with fibromyalgiaPharmacotherapy 24(11):1646-1648, 2004. © 2004

Pharmacotherapy PublicationsReferences:1. Olson NJ, Park JH. Skeletal muscle abnormalities in patients with fibromyalgia. Am J Med Sci 1998;315:351-8.2. Bengtsson A, Henriksson KG, Larsson J. Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia. Arthritis Rheum 1986;29:817-21.3. Eisinger J, Plantamura A, Ayavou T. Glycolysis abnormalities in fibromyalgia. J Am Coll Nutr 1994;13:144-8.4. Park JH, Phothimat P, Oates CT, Hernaz-Schulman M, Olsen NJ. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum 1998;41:406-13.5. Leventhal LJ. Management of fibromyalgia. Ann Intern Med 1999;131:850-7.6. Friedberg F, Jason LA. Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment. J Clin Psychol 2001;57:433-55. Lash AA, Ehrlich-Jones L, McCoy D. Fibromyalgia: evolving concepts and management in primary care settings. Medsurg Nurs 2003;12:145-59, 190.7. Briley M, Moret C. Fibromyalgia syndrome: an overview of potential drug targets. Drugs 2003;6:668-73.8. Holdcraft LC, Assefi N, Buchwald D. Complementary and alternative medicine in fibromyalgia and related syndromes. Best Pract Res Clin Rheumatol 2003;17:667-83.9. Wolfe F, for the American College of Rheumatology. Criteria for the classification of fibromyalgia: report of the multi-center criteria committee. Arthritis Rheum 1990;33:160-72.10. St Cyr J, Bianco R, Schneider J, et al. Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model. J Surg Res 1989;42:157-62.11. Hellsten Y, Skadhauge L, Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Integr Comp Physiol 2004;286:R182-8.12. Williamson DL, Gallagher PM, Goddard MP, Witter J, Trappe S. Effects of ribose supplementation on adenine nucleotide concentration in skeletal muscle following high-intensity exercise [abstr]. Med Sci Sport Exer 2001;33(5 suppl).13. Ingwall JS. ATP and the heart. Boston: Kluwer Academic, 2002:55-95.14. Pauly DF, Pepine CJ. D-ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther 2000;5: 249-58.15. Pliml W, von Arnim T, Stablein A, Hoffman H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.16. Butler T, St Cyr J. Use of ribose to prevent cramps and soreness in muscles. U.S. patent 6159943. December 12, 2000.17. Zarzeczny R, Brault JJ, Abraham KA, Hancock C, Terjung R. Influence of ribose on adenine salvage after intense muscle contractions. J Appl Physiol 2001;91:1775-81.18. Van Gammeren D, Antonio J, Falk D. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo controlled trial. Cur Therapeut Res 2002;63:486-95.19. Berandi JM, Ziegenfuss TN. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res 2003;17:47-52.20. Falk DJ, Heelan KA, Thyfault JP, Koch AJ. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. J Strength Cond Res 2003;17:810-16.21. Schneider J, St Cyr J, Mahoney J, Bianco R, Ring W, Foker J. Recovery of ATP and return of function after global ischemia [abstr]. Circulation 1985;72(4 pt 2):III-298.22. Zimmer HG. Normalization of depressed heart function in rats by ribose. Science 1983;220:81-2.23. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Failure 2003;5:615-19.24. Lund E, Kendall SA, Janerot-Sjoberg B, Bengtsson A. Muscle metabolism in fibromyalgia studied by P-31 magnetic resonance spectroscopy during aerobic and anaerobic exercise. Scand J Rheumatol 2003;32:138-45.Source: MedScape

Missing Nutrients

Many people, desperate for relief from constant suffering from fibromyalgia and chronic pain, have opted for surgery, physical therapy and/or pain medications, including anti-depressants, and still they say "I hurt all over."

Using prescription medications, such as antidepressants, tranquilizers and pain medications, only treats the symptoms. Prescription medications only use the current supply of neurotransmitters and nutrients and do not create any new neurotransmitters (the chemical language of the brain).

Pain, stress, anxiety and depression burn the amino acids and minerals the body must have for proper functioning. One must constantly replenish the brain with needed nutrients.

When nutrient deficiencies are reversed, then the problem is addressed and healing is enhanced. The proper nutrients can have a positive effect on pain and the anxiety and depression that come with it.

To focus on assisting those who suffer from FM and chronic pain, it is necessary to understand what is happening in the body and the brain. An increased level of muscle tissue breakdown has been suggested as one of the main reasons for aching, pain and fatigue. The onset may be gradual or sudden. Symptoms may appear after an illness or a traumatic or stressful episode in one's life.

FM can occur within the muscles or where muscles join their tendons, rather than in the joints. Tension and stress, poor posture, rapid repetitive motions or incorrectly using the muscles to push, lift or pull can aggravate FM.

Anxiety and depression will almost always follow.

A major factor in the successful treatment of FM, as well as chronic pain, is specific nutrients that exert a strong regenerative effect on the body's systems, including the nervous system.

Missing Nutrients

Recent research has shown that FM patients may be deficient in certain compounds required for the synthesis of ATP (Adenosine Triphosphate).

One of the most crucial elements for ATP synthesis is magnesium. Research suggests FM patients have below-normal levels of magnesium. Low levels of magnesium can contribute to PMS, headaches, muscle cramping, muscle spasms, heart palpitations and even heart attacks. Many common foods Americans eat deplete magnesium reserves. According to reports, at least 85 percent of magnesium is removed by eating bleached and refined flour in breads, pasta and other prepared wheat products.

Soft drinks have a high phosphorus content, which also reduces magnesium levels in the body. Even high-calcium supplementation, without adequate magnesium, will deplete the body's level of magnesium.

Malic Acid
Aluminum toxicity may play a role in symptoms experienced by magnesium-deficient FM patients. As a preventative measure, adequate amounts of magnesium can help block the toxic effects of aluminum. However, the most potent; aluminum detoxifier is malic acid. Malic acid is especially effective at decreasing aluminum toxicity in the brain. Alzheimer's Disease patients have been found to have unusually high levels of aluminum in their brains. It was once assumed that these people had ingested large amounts of aluminum during their lifetimes. However, while that may be true, it is now thought that how much aluminum is consumed is not nearly as important as how well our bodies can detoxify and eliminate the substance.

Treatment with malic acid has been shown to greatly increase the fecal and urinary excretion of aluminum and reduce the concentration of aluminum found in various organs and tissues.

Clinical tests are proving malic acid to be a great asset in the treatment of FM and chronic pain. In one clinical study, reported in "The Journal of Nutritional Medicine," 15 patients (aged 32-60) taking a dosage of 200-2400 mg. of maIic acid with 300-600 mg of magnesium for four to eight weeks, reported significant pain relief within 48 hours. These positive effects continued to increase over the test period.

The mineral manganese and B complex vitamins have also been shown to be deficient in both CFS (Chronic Fatigue Syndrome) and FM sufferers. Combinations of GABA, glutamine and glycine, (inhibitory neurotransmitters) have been helpful in lowering stress levels by controlling limbic firing in the brain.

Fibromyalgia, Pain Relief & Energy with Malic Acid

Malic Acid, Energy, & Fibromyalgia

Improvement in pain observed within 48 hours of supplementation with 1200-2400 mg. of malic acid per day. Buy Metagenics Fibroplex with magnesium and malic acid at a discount

Combine Bioenergy Corvalen Ribose with Metagenics Fibroplex for muscle pains and energy - Corvalen Lowest Price with Free Shipping

Primary fibromyalgia (FM) is a condition affecting principally middle-aged women, characterized by a syndrome of generalized musculoskeletal pain, aches, stiffness, and tenderness at specific anatomical sites. This condition is considered primary when there are no obvious causes. Since it was first described, FM has become recognized as a fairly common rheumatic complaint with a clinical prevalence of 6 to 20 percent. Additionally, FM has been associated with irritable bowel syndrome, tension headache, mitral valve prolapse, and chronic fatigue syndrome.

Numerous treatment modalities have been attempted to treat patients with FM, but unfortunately the results have usually been poor. The primary reason for this lack of success was undoubtedly due to our lack of understanding FMs etiology.

In recent years, evidence has accumulated to suggest that FM is the result of local hypoxia in the muscles. For instance, patients with FM have low muscle-tissue oxygen pressure in affected muscles, and to a lesser degree the same was found in other tissues. Muscle biopsies from affected areas showed muscle tissue breakdown and mitochondrial damage. Additionally, low levels of the high energy phosphates ATP, ADP, and phosphocreatine were found.

It has been hypothesized that in hypoxic muscle tissues glycolysis is inhibited, reducing ATP synthesis. This stimulates the process of gluconeogenesis, which results in the breakdown of muscle proteins to amino acids that can be utilized as substrates for ATP synthesis. This muscle tissue breakdown, which has been observed in muscle biopsies taken from FM patients, is hypothesized to result in the muscle pain characteristic of FM.

Malic acid is both derived from food sources and synthesized in the body through the citric acid (Krebs) cycle. Its importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acids simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxias inhibition of glycolysis and energy production. This may allow malic acid to improve energy production in FM, reversing the negative effect of the relative hypoxia that has been found in these patients.Because of its obvious relationship to energy depletion during exercise, malic acid may be of benefit to healthy individuals interested in maximizing their energy production, as well as those with FM.

In the rat it has been found that only tissue malate is depleted following exhaustive physical activity. Other key metabolites from the citric acid cycle needed for energy production were found to be unchanged. Because of this, a deficiency of malic acid has been hypothesized to be a major cause of physical exhaustion. The administration of malic acid to rats has been shown to elevate mitochondrial malate and increase mitochondrial respiration and energy production. Surprisingly, relatively small amounts of exogenous malic acid were required to increase mitochondrial energy production and ATP formation.

Under hypoxic conditions there is an increased demand and utilization of malic acid, and this demand is normally met by increasing the synthesis of malic acid through gluconeogenesis and muscle proteinbreakdown. This ultimately results in muscle breakdown and damage.In a study on the effect of the oral administration of malic acid to rats, a significant increase in anaerobic endurance was found. Interestingly, the improvement in endurance was not accompanied by an increase in carbohydrate and oxygen utilization, suggesting that malic acid has carbohydrate and oxygen-sparing effects. In addition, malic acid is the only metabolite of the citric acid cycle positively correlated with physical activity. It has also been demonstrated that exercise-induced mitochondrial respiration is associated with an accumulation of malic acid.

In humans, endurance training is associated with a significant increase in the enzymes involved with malic acid metabolism.Because of the compelling evidence that malic acid plays a central role in energy production, especially during hypoxic conditions, malic acid supplements have been examined for their effects on FM. Subjective improvement in pain was observed within 48 hours of supplementation with 1200 - 2400 milligrams of malic acid, and this improvement was lost following the discontinuation of malic acid for 48 hours.

While these studies also used magnesium supplements, due to the fact that magnesium is often low in FM patients, the rapid improvement following malic acid, as well as the rapid deterioration after discontinuation, suggests that malic acid is the most important component. This interesting theory of localized hypoxia in FM, and the ability of malic acid to overcome the block in energy production that this causes, should provide hope for those afflicted with FM.

The potential for malic acid supplements, however, reaches much farther than FM. In light of malic acids ability to improve animal exercise performance, its potential for human athletes is particularly exciting.Additionally, many hypoxia related conditions, such as respiratory and circulatory insufficiency, are associated with deficient energy production. Therefore, malic acid supplements may be of benefit in these conditions.

Chronic Fatigue Syndrome has also been found to be associated with FM, and malic acid supplementation may be of use in improving energy production in this condition as well. Lastly, malic acid may be of use as a general supplement aimed at ensuring an optimal level of malic acid within the cells, and thus, maintaining an optimal level of energy production.

Metagenics Fibroplex has: Thiamin (as thiamin mononitrate) 50 mgVitamin B6 (as pyridoxine HCl) 50 mgMagnesium (as magnesium bis-glycinate†) 150 mgManganese (as manganese glycinate†) 5 mg., Malic Acid 600 mg

Metagenics Fibroplex® Plus - Support for Muscle Tenderness and DiscomfortFibroplex® Plus provides targeted nutritional support for soft tissues in those with muscle tenderness and discomfort. Featuring a blend of specific vitamins, minerals, and amino acids in an easy-to-use delivery form, this specialized formula works by supporting cellular energy production and muscular and nervous system function.
  • Provides targeted nutrition for soft tissue in those with muscle tenderness and discomfort.
  • Provides targeted support for energy metabolism and neuromuscular function.
  • Supports cellular energy production and mitochondrial function.
  • Provides magnesium in the form of an amino acid chelate designed to be easily absorbed.